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The recommended dose of pemetrexed for injection when administered with cisplatin for initial treatment of locally advanced or metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes administered prior to cisplatin on Day 1 of each 21-day cycle for up to six cycles in the absence of disease progression or unacceptable toxicity

Genau auf dieser Beziehung basiert die IU-Berechnung

In addition, R66 forms a cation- interaction with F300 and a hydrogen bonding network with the surrounding residues L61, L70, Q297, D459 and S464 to stabilize the closed EC-gate (Fig