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Though it follows a similar mechanism as GHK-Cu by signaling copper, its skin-specific benefits remain an area where additional research is developing

These membranes were probed with SURVIVIN (#AF886, R&D Systems, Waltham, MA), BMI-1 (#sc-10745, Santa Cruz, CA, USA), Caspase-3 (#9662, Cell Signaling, MA, USA), PARP (#9542, Cell Signaling, MA, USA), E-cadherin (#610181, BD Bioscience, San Jose, CA), N-cadherin (#4061, Cell Signaling, MA, USA), VIMENTIN (#sc-32322, Santa Cruz, CA, USA), MMP2 (#13132, Cell Signaling, MA, USA), phospho AKT (#4060, Cell Signaling, MA, USA), AKT (#4691, Cell Signaling, MA, USA), phospho ERK (#612358, BD Bioscience, San Jose, CA), ERK (#9102, Cell Signaling, MA, USA), MCL-1 (#4572, Cell Signaling, MA, USA), FBW7 (#ab10752, Abcam, Cambridge, MA), and -actin (#3700, Cell Signaling, MA, USA) primary antibodies, followed by incubation with secondary antibodies conjugated to horseradish peroxidase (Santa Cruz Biotechnology, CA, USA)

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Dowlatshahi EA, van der Voort EAM, Arends LR, et al