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HIF-1 induces endothelial to mesenchymal transition by promoting the activity of the transcription factors Twist, Snail, and ZEB2, thereby stimulating angiogenesis

Sometimes, the injury is called tennis leg. Advertisement Other risk factors for calf strains include: Depending on the severity of your condition, complications of a pulled calf muscle may include: A healthcare provider will perform a physical exam and review your symptoms

However, research protocols often compare systemic (subcutaneous) administration with localized administration to determine if one is more effective for a specific injury model.