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HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation

Three fermentation replicates were prepared per treatment, resulting in a total of 15 vessels, each containing 40 kg of mash

"The test points to an overall pattern of gut health or dysfunction, which you can then address clinically through nutrition, lifestyle strategies, and supplements." The goal isn't simply the absence of pathogens but optimizing a healthy gut microbiome to promote health

In addition, we evaluate the translational relevance of these molecular insights in clinical practice, with emphasis on diagnostics, transfusion medicine, and emerging therapeutic strategies