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Many individuals with plaques and tangles do not become dementedthe clinical expression of the disease seems to be partly determined by co-morbid conditions such as brain infarcts and small vessel disease

10.1111/j.1471-4159.2004.02459.x 278 YanchevaS.IhlR.NikolovaG.PanayotovP.SchlaefkeS.HoerrR.et al (2009)

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Oral & even IM treatment with Cyano-B12 were ineffective, but IM treatment with your Methyl-B12 so far appears to be very effective