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Supplementary Figure S7, LC CD4 p = 0.69, CD8 p = 0.55), metformin had a statistically significant effect in reducing CD4 T cell hyperproliferation in ME/CFS female donors (Figure 5E, CD4 9.8% reduction in proliferation p = 0.041, CD8 10.5% reduction in proliferation p = 0.39)

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More recently, loss of cardiac MIBG uptake was linked with a body first as opposed to brain first phenotype, with associated loss of 11C-donepezil PET-CT signal, reflecting reduced cholinergic parasympathetic innervation 38