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KNO1-mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination

For the vascular side, GHK-Cu promotes angiogenesis through VEGF and bFGF expression, improves blood vessel integrity, and supports microcirculation

10.1016/j.bbrc.2011.05.155 47 FarkasG.KirlyZ.SolymosiF

Ultimately, this FOXO4-DRI-mediated mechanism selectively eliminates senescent endothelial cells, which in turn attenuates vascular inflammation and improves endothelial-dependent vasodilation, conferring a significant protective effect on vascular function