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J., Chen, Y

The ligand was spiked out of the protein at 60ns, and then it rejoined the protein at 90ns with major fluctuation (1048)

Ravna AW et al (2009): Structure and localisation of drug binding sites on neurotransmitter transporters

RSL3, a ferroptosis inducer, directly acts on GPX4 and inhibits its activity, thus reducing the antioxidant capacity of cells and accumulating ROS, leading to ferroptosis 12