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The practical implication is straightforward

AHK-Cu Synonyms / Designations: GHK-Cu, Copper Tripeptide-1, Glycyl-L-histidyl-L-lysine copper complex CAS Number: 49557-75-7 Molecular Formula: C14H24CuN6O4 Molecular Weight: 403.92 g/mol Purity: 99 % (HPLC) Appearance: Blue to deep blue lyophilised powder Pack Size: 50 mg (total) Storage: Desiccated, protected from light, stored at 20 C or below Solubility: Water and buffered aqueous solutions

Nevertheless, the IM route of either OH-Cbl or CN-Cbl remains more established and widely recommended for treatment of B12 deficiency

Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide