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Description

when this channel becomes mislocalized, it may facilitate the spread of ROS, further exacerbating oxidative stress [436, 437]

& McHugh, K

10.1007/s13105-015-0462-4 104 LvH.HuY.CuiZ.JiaH

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans