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Abbreviations EVs: Extracellular vesicles EndMT: Endothelial-to-mesenchymal transition FAP: Fibroblast activation protein () FOLFIRINOX: Folinic acid, 5-FU, irinotecan, oxaliplatin (combination chemotherapy regimen) FeCO: Carbonyl iron Foxp3: Forkhead box P3 G-CSF: Granulocyte colony-stimulating factor GEM: Gemcitabine GSH: Glutathione Gal-9: Galectin-9 HIF-2: Hypoxia-inducible factor-2 HLA-A: Human leukocyte antigen A IDH3A: Isocitrate dehydrogenase 3 (alpha subunit) IFN-: Interferon-gamma IGF-1: Insulin-like growth factor 1 IGF1R: Insulin-like growth factor 1 receptor IL1RAP: Interleukin-1 receptor accessory protein JAK: Janus kinase LDH: Lactate dehydrogenase LPA: Lysophosphatidic acid LPC: Lysophosphatidylcholine LRRC15: Leucine-rich repeat-containing 15 LncRNA: Long non-coding RNA MAPK: Mitogen-activated protein kinase MCT1: Monocarboxylate transporter 1 MCT4: Monocarboxylate transporter 4 MDSCs: Myeloid-derived suppressor cells MHC II: Major histocompatibility complex class II MMPs: Matrix metalloproteinases MSC: Mesenchymal stem cell NOD1: Nucleotide-binding oligomerization domain 1 NUFIP1: Nuclear fragile X-interacting protein 1 OXPHOS: Oxidative phosphorylation PC: Phosphatidylcholine PEGPH20: Pegylated hyaluronidase PH20 (pegvorhyaluronidase alfa) PKM2: Pyruvate kinase M2 PLAU: Plasminogen activator, urokinase PNI: Perineural invasion PSCs: Pancreatic stellate cells PTGS2: Prostaglandin-endoperoxide synthase 2 PTP: Plectin-1 targeted peptide SCD1: Stearoyl-CoA desaturase 1 SDF-1: Stromal cell-derived factor 1 STAT3: Signal transducer and activator of transcription 3 STING: Stimulator of interferon genes TAK1: TGF--activated kinase 1 TAMs: Tumor-associated macrophages TCA: Tricarboxylic acid (cycle) TGF-: Transforming growth factor-beta TME: Tumor microenvironment TNF-: Tumor necrosis factor-alpha Tregs: Regulatory T cells VM: Vascular mimicry -SMA: Alpha-smooth muscle actin apCAF: Antigen-presenting CAF iCAF: Inflammatory CAF mPSCs: Mouse pancreatic stellate cells myCAF: Myofibroblast CAF scRNA-seq: Single-cell RNA sequencing References Blackford AL, et al