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Furthermore, we showed that the suppression of the core subunit of the Arp2/3 complex, ARPC2, using a previously validated shRNA (Saito et al, 2017), abrogated the ciliary resorption acceleration caused by the MAST4 WT overexpression (Fig S8)

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As GPX4 plays a critical role in preventing ferroptosis, the CSDS-induced downregulation and EDV-induced upregulation of GPX4 suggest that ferroptosis contributes to depression development