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This chain of events fails to occur in the corticosteroids animals after initial inflammation inhibition (Sikiric et al., 2003)

Dimethyl fumarate protects against hepatic ischemia-reperfusion injury by alleviating ferroptosis via the NRF2/SLC7A11/HO-1 axis

Formaldehyde is formed in mammalian cells from demethylation reactions, the oxidative breakdown of folates and the metabolism of methanol, methylamine and adrenaline 5,6

Then they tested the synergistic effect of these two compounds, and interestingly, they showed promising results on the modulation and opening of Kv channels isoform KCNQ25, and the activation of these channels is of critical importance in the control of seizure, action potential, and repolarization