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Recently, it is also considered to be one of the factors leading to the development of neurodegenerative and neuroinflammatory diseases of the central nervous system, e.g., multiple sclerosis, Alzheimers disease, or Parkinsons disease [25,29,30]

Specific alterations in the expression of the urea cycle enzymes in different cancers profoundly affect nitrogen-containing macromolecules, such as nucleotides and proteins, which are associated with tumor initiation and progression, even immunotherapy response (Lee et al., 2018)

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