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First results from the Phase 1 study of APL-4098, an oral potent GCN2 inhibitor for the treatment of relapsed/refractory acute myeloid leukemia (R/R AML) and myelodysplastic syndromes (MDS)/AML

Results: Human liver slices in contact with MEECs exhibited greater viability than slices exposed to acellular matrices (ATP/Protein, 1.40.5 pmol/g vs 1.90.5, p 0.8)

Nanosystems improve solubility, stability, and bioavailability of their drug cargos making them especially valuable for treating cancers 91 , cardiovascular diseases 92 , and inflammatory conditions 93