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It has been demonstrated that the promotion of HDAC4 phosphorylation is found after overexpression of CDKL5 via facilitating the cytoplasmic retention of HDAC4 while loss of CDKL5 leads to the decrease of HDAC4 phosphorylation, ultimately increasing the translocation of HDAC4 into the nucleus [105]

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The analysis revealed that both the comproportionation and triad models were better suited to represent the experimental data than the reduced model, but were inconclusive with respect to overall model selection, given that both AIC/BIC values were extremely similar (Fig

10.1073/pnas.1315943111 63 GelderblomM.LeypoldtF.SteinbachK.BehrensD.ChoeC.-U.SilerD