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162 Furthermore, although it has been shown to improve pain, fatigue, depression, and sleep quality in the short term, long-term cyclobenzaprine has been found to be no more effective than placebo for treating fibromyalgia and other chronic pain conditions

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This effect may be mediated by inhibiting Wnt-driven epithelial proliferation and dysfunction, and by correcting solute transport disorders that control the physiological balance of the Na + /Cl - (decreased fecal Na + and Cl - levels, increased serum Na + and Cl - levels), and reducing serum total protein [87,88,89]

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