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First, there's injury or degradation, whether from aging, sun damage, or physical trauma

This is especially relevant in neurodegenerative diseases, where targets such as amyloid beta plaques, inflammatory cell populations, or vulnerable neuronal circuits may be unevenly distributed across brain regions

reported a cytokine delivery platform as interleukin-2-producing cytokine factory organized with polymer and ARPE-19 cells which can be clinically translatable (Fig