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Plant [edit] In vivo , plant PPOs are expressed as about 6468 kDa proteins consisting of three domains: a chloroplastic transit peptide (containing a ~4-9 kDa thylakoid signal peptide), a catalytically active domain (~ 3742 kDa) containing the dinuclear copper center, and a C-terminal domain (~1519 kDa) shielding the active site