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The size of the pressure differential between IOP and the optic nerve is unknown and it remains unclear that it is affected by cerebrospinal fluid pressure, whether and how stretch of scleral tissues contributes to RGC injury, whether certain RGC classes (which?) are selectively sensitive/resistant to IOP, why retinal glia are so sensitive to elevated IOP, what (if any) is the role of ischemic compression at moderate IOP elevations and which signaling pathways mediate the acute vs

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