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To the extent that both compounds have been used in clinical settings, the available data indicate vastly different dosage recommendations, frequency of use, and routes of administration: MK-677 is taken as oral capsules, usually once daily, thanks to its relatively long half-life

Klusek et al ., 2020

While this can be incredibly invalidating and frustrating, it helps to understand that their skepticism is often rooted in a lack of institutional training rather than malice