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Firstly, restricted carbohydrate intake in KD leads to a reduction in glycolysis, the primary pathway of glucose catabolism, which is responsible for the production of NADH (140)

Despite being considered"undruggable"for decades due to its small and shallow surface, recent developments of irreversible covalent inhibitors for KRAS G12C , like AMG510 (Sotorasib) and MRTX849 (Adagrasib), have shown promising clinical outcomes, making mutant KRAS a"druggable"target [52,53,54,55]

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These result were further confirmed for their pathogenicity of GSR gene using SNPs&GO, Mutation tester, SNAP2, and PROVEAN server