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Antioxidant and anti-inflammatory effects of IGF-I have been documented to reduce atherosclerotic burden, mainly both via cytokine response modulation (attenuating IL-6 and TNF- pro-inflammatory responses)[299] and/or eNOS activity regulation[295]

In parallel, to determine the effect of inulin supplementation on HFCS-elicited pathologies, we used an open-source diet, a control diet used in many nutritional studies 36,37,38 , and formulated an inulin-enriched diet by replacing a small portion of corn starch (10% w/w) with inulin, as in previous studies 39,40,41 (Supplementary Table 1)

Reactive derivatives of oxygen, termed reactive oxygen species (ROS), are toxic for non-target molecules 2 , causing oxidative damage to nucleic acids, proteins and lipids 3 , reviewed by 4,5

Glutathione and Immune Function Kim, K