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All copper peptides share similar potential side effects: temporary redness, irritation with high concentrations, and possible allergic reaction in those with copper sensitivity

This has been attributed to increased mechanical fragility (iron deficient RBC are more rigid and more likely to fragment as they traverse through small capillaries under high shear), however oxidative injury to red blood cells is likely contributing to keratocyte formation (Yoo et al 2009) (given that antioxidant enzymes in red blood cells, such as glutathione peroxidase, contain iron)

Therefore, we extracted and compared the metatranscriptome data annotated to Lachnospiraceae and Citrobacter (Fig