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For example, the increase of Bcl-2 can act an anti-apoptotic role by regulating Ca 2+ concentration, and possess a protective effect on myocardial injury ( 2.4 Mitochondrial dynamics Mitochondria are highly dynamic organelles that regulate their form, distribution and function through fusion and fission cycles, which are known as mitochondrial dynamics (Dorn et al., 2015) (Figure 2B)

Kalinina, E

We found that PPARa over-expression significantly up-regulated FSP1 expression in neuron after TSCI, thus promoted the expression of CoQ10 and content of NADH, while icFSP1 inhibited this phenomenon, suggesting that FSP1 is a key effector of PPARa mediated lipid peroxidation related neuronal ferroptosis protection