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These distinctions highlight that the mode of GSH depletion, i.e., via acute blockade of synthesis versus more gradual enhanced degradation, can differentially influence the oxidative stress response, secondary transcriptional programs, and systemic physiology

Chem Senses 29(3):179187 Sudarshan G, Weil S, Jasika W, Manor R, Goldstein O, Aflalo ED, Ofir R, Zimin SV, Levy T, Rosental B, Brotman Y, Sagi A (2023b) Correlation between metabolomic profile and proliferation of Macrobrachium rosenbergii primary embryonic cell culture

Because this phase typically peaks and begins transitioning into the remodeling phase around the 21-to-30-day mark, a 4-week administration window provides the necessary stimulus exactly when the cellular machinery is most active [3, 5]

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