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Conversely, NRF2 activation has been shown to suppress ROS production and preserve renal function in various kidney injury models [47, 48]

Javonillo DI, Tran KM, Phan J, Hingco E, Kramr EA, da Cunha C, Forner S, Kawauchi S, Neumann J, Matheos DP, Rezaie N, Alcantara JA, Mortazavi A, Wood MA, Tenner AJ, MacGregor GR, Green KN and LaFerla FM (2021) Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimers disease