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Additionally, chronic inflammatory activation of astrocytes reduces their support functions for neurons, exacerbating neuronal dysfunction (107)

Resident-intruder paradigm In this experiment, mice that had been socially isolated, each living alone in its own cage for four weeks, were brought into the testing room one by one

Pitfalls The nomogram may fail to predict the risk of hematotoxicity when any of the following confounders are present: Misleading history about the time of intoxication

PGI-C response of moderately improved or much improved. This group of patients, often refractory to treatment, had higher response rates with ritlecitinib than with placebo, although rates were lower than in patients without AT or AU.8 Patients with abnormal eyebrow or eyelash scores Among patients without normal eyebrow or eyelash assessment scores at baseline, improvement by 2 grades in eyebrow score or normalization of eyelash score increased over time across all four ritlecitinib groups (Fig