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They are the precursors of plasma cells

In another study evaluating the potential of Pinoresinol-4- O --d-glucopyranoside (Pgu) using the lithium/pilocarpine-induced rat model, seizure induction caused an increase in the levels of malondialdehyde (MDA) a marker of oxidative lipid damageand decreased catalase activity, while also increasing the expression levels of PTGS2, all of which was reversed by Pgu pretreatment, which also mitigated neurodegeneration 47

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Consequently, wild-type p53 suppresses NADPH production, whereas tumor-associated p53 mutants show almost no activity in inhibiting G6PD, thereby maintaining a high level of NADPH production