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Early introduction of palliative care after a first episode of liver decompensation resulted in significantly better HRQoL at 1 year compared with the standard of care

Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation.Hepatology1998;28 1022-30

Together, the cumulative cardiovascular strain increases risk of tachycardia, atrial arrhythmias, and hypertensive episodesparticularly in patients with pre-existing heart disease or borderline blood pressure control