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doi:10.2174/1381612828666220620160516 Inoue K, Ritz B, Brent GA, Ebrahimi R, Rhee CM, Leung AM

Ceramides - lipotoxic inducers of metabolic disorders

It is postulated that AGEs participate in the pathological mechanism of cardiovascular disease, nephropathy, rheumatoid arthritis, dysfunctions in bone remodelling and neurological diseases (for example, Alzheimer's and Parkinson's disease), cancer growth, metastasis and other degenerative diseases (9,20-22)