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SCD arises from an atypical HbS (2S2) where in the amino acid glutamic acid residue at position 6 in the -globin chain of haemoglobin is substituted with valine

Furthermore, methotrexate (MTX), the immunosuppressant commonly used for the treatment of RA, has been demonstrated that could reduce inflammation and subsequent tissue damage by inhibiting MAA-adducts formation and scavenging superoxide in RA [108]

Nevertheless, allogenic cells, often utilized in regenerative therapies, have intrinsic limits and obstacles, including immunological reactivity, tumorigenic potentials, and ethical issues

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