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These changes in GSH levels have the potential to yield clinical benefits, as illustrated in Figure 3

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A major limiting factor in the development of new treatments is the lack of predictive pre-clinical models that accurately reflect human disease with regard to liver histology, pathophysiology, and metabolic abnormalities

In this study, PLGA-PEG nanoparticles induced expression of autophagy-associated genes autophagy related 3 ( ATG3 ), DNA damage regulated autophagy modulator 2 ( dram2 ), GABA type A receptor associated protein like 2 ( GABARAPL2 ), and RAB24, member RAS oncogene family (RAB24), (Fig 5A)