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Binding affinities for titrations were all fit to the following equation: Y = Fmax*(A sqrt(A^2-B))/(2*C), where X is the concentration of inhibitor, Fmax is the maximum chemical shift change, A = ([BLVRB] + X + KD), B = 4*[BLVRB]*X, and C = [BLVRB]

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Earlier studies examined specific, individual loci, but epigenome-wide association studies (EWAS) have identified a greater number of loci