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It therefore appears that the TS pathway gradually evolved from early eukaryotes like Giardia and Entamoeba to intracellular Apicomplexans like Plasmodium to a fully functional pathway in Kinetoplastids like Trypanosoma

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Notably, the rate of post-exercise phosphocreatine (PCr) resynthesisa direct marker of in vivo mitochondrial oxidative phosphorylation capacityhas been positively correlated with the recovery of muscle endurance following exercise (84)