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Citrinin biomarkers: a review of recent data and application to human exposure assessment

First of all, intracellular iron generally exists in the form of Fe 2+ , which can produce OH through the Fenton reaction, and then react with polyunsaturated fatty acids in the plasma membrane to produce ROS, resulting in iron-regulated death

Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons