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Altered miRNA profiles have been reported in the cochlea following acoustic trauma, and in tinnitus models induced by other etiologies such as salicylate, suggesting that miRNA dysregulation may contribute to maladaptive responses to peripheral injury (Patel et al., 2013)

In addition, the tubular ultrafiltrate from nephrotic rats stimulated collagen types I and IV synthesis in cultured tubular cells, suggesting that the excessive losses of IGF-1 in the nephrotic state may promote tubular-interstitial fibrosis and thereby, progressive kidney disease in patients with persistent nephrotic syndrome [219]