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This bacterial infection progresses from reversible gingivitis to periodontitis, affecting nearly 50% of adults over 30 and becoming the leading cause of tooth loss in adults

Casuarinin, isolated from SBT leaves, showed inhibitory effects on TNF--induced ICAM-1 expression in human keratinocytes, suggesting its potential as an anti-inflammatory agent (156)

It has been observed that there is a correlation between inflammation and CAD, wherein inflammation has been found to impede the production of endothelial nitric oxide

Treatment with the ferroptosis inhibitor Fer-1 significantly reduced the tumor M2/M1 ratio, indicating that ferroptosis inhibition promotes the polarization from M2 to M1 ( 3.1.4 MDSCs Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature myeloid cells that are significantly expanded in GBM and promote tumor immune escape through the suppression of immune cells such as T cells ( 3.1.5 DC Dendritic cells (DCs) are key antigen-presenting cells (APCs) that initiate primary T-cell responses