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The findings of this study also lend support to previous studies demonstrating that NIDA-41020 administration blocked THC, ethanol, and nicotine self-administration and reinstated substance-seeking behaviors in rodents ( Previous molecular and histology studies showed that in the mesocorticolimbic reward pathway, a significantly high density of CB 1 receptor protein was localized on both GABAergic and glutamatergic axon terminals of the hippocampus, whereas a modest CB 1 receptor localization was reported throughout the neocortex, VTA, amygdala, periaqueductal gray nucleus, nucleus accumbens, and medial hypothalamus (Tsou et al., 1998