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Bowers, GHRP-6 was the first compound in the GHRP family and the foundation from which all subsequent GH secretagogues including GHRP-2, hexarelin, and ipamorelin were derived

But GHRP-2 still raises cortisol and prolactin, though to a lesser degree than GHRP-6

MAPK/ERK Proliferation Pathway IGF-1 LR3 also activates the mitogen-activated protein kinase (MAPK/ERK) signaling pathway through Ras-Raf-MEK-ERK activation

Ipamorelin's high level of selectivity has made it a subject of great interest in research, as it can serve as a therapeutic agent and a model peptide to uncover the mechanisms behind receptor binding selectivity