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2016;26(9):1021-1032.[DOI] 16

So no loading doses , no matter how fast the providers want you to go up on the dose (and we know you have pressure to get them out of the door)

10.1097/TP.0000000000004038 21 DingH.JiangL.XuJ.BaiF.ZhouY.YuanQ.et al (2017)

The drug is metabolized by different hepatic pathways but mainly by conjugation with sulfate and glucuronic acid to produce 4-acetamidophenol sulfate and 4-acetamidophenol glucuronide respectively