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For C 60 , the HOMO is at 5.25 eV and the LUMO at 3.58 eV, giving a HOMO-LUMO gap of 1.67 eV, indicating moderate reactivity (Fig

doi: 10.1161/CIRCULATIONAHA.107.758524, 82 LouF.LuoS.KangN.YanL.LongH.YangL.et al

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or an N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof, with the proviso that: when R 3 is ethyl, R 1 and R 2 cannot be both H, O, or when R 3 is ethyl and at least one of R 1 or R 2 is H, R 1 or R 2 cannot be As used herein, ferroptosis means regulated cell death that is iron-dependent