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Thyroid dysfunction, especially hypothyroidism, that occurs in high incidence during TKI therapy has a close relationship with treatment efficacy, but the mechanism of TKI-induced thyroid dysfunction is obscure

It was actually used to treat hyperthyroidism up until the 1950s, as it is an effective thyroid suppressor at daily doses of 0.9 to 4.2 mg

LC-MS/MS pharmacokinetic characterization of 5-amino-1-methylquinolinium in rat plasma, J Pharm Biomed Anal , 2021

The multiple phosphoinositides that result can activate key signaling proteins, including RAL, RAC, RHO, FADK, AKT, PKC and calmodulin (CALM), that signal downstream events in the pathways of inflammation, antioxidant responses, stress responses, cell movement (cancer-cell invasion), and endocytosis