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These findings highlight the importance of EAAT2 localization and trafficking for normal synaptic function, and provide a theoretical basis for novel pathophysiological mechanisms in neuropsychiatric diseases

These include positive regulators, such as ferredoxin 1 (FDX1) , lipoic acid synthase (LIAS) , lipotransferase 1 (LIPT1) , dihydrolipoamide dehydrogenase (DLD) , thiolipoamide S-acetyltransferase (DLAT) , pyruvate dehydrogenase E1 subunit 1 (PDHA1) , and pyruvate dehydrogenase E1 subunit (PDHB) , as well as negative regulators, like metal-responsive transcription factor-1 (MTF1) , glutaminase (GLS) , and cyclin-dependent kinase inhibitor 2 A (CDKN2A) [25]

Vitamin and Cofactor Chemistry Glutathione interacts with other redox systems, including pathways involving vitamin C, thioredoxin and NADPH

Note that in many cases the density barrier enrichment of DCs is followed by further purification using antibody-bound beads 2