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Then weve also started to move into clinical trials

GLP-1 helps lower blood glucose (blood sugar) by triggering insulin release

GLP-1responsive -cells exhibit enhanced glucose-stimulated insulin secretion through activation of the cAMP-dependent signaling cascade: ligand binding to GLP-1R stimulates adenylyl cyclase, elevates intracellular cAMP levels, and sequentially engages both PKA- and Epac2-mediated pathways, thereby promoting insulin-granule exocytosis and increasing the secretory competence of -cells (Luo et al., 2013)