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Because deficiency can be associated with anemia and neurologic problems, persistent changes deserve veterinary attention rather than guesswork

Conserved amino-acid residues (six cysteines, one arginine, and one glutamate residue of DEFA5L) show a sequential arrangement that is similar to most other mammalian -defensins [40]

Deficiency is widespread in the UK due to limited sunlight exposure, and is particularly prevalent in those with chronic illness, darker skin tones, or conditions affecting fat absorption

This aligns with ongoing investigations into gut-brain interactions, oxidative balance, and systemic homeostasis