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Furthermore, animal research has found that extremely high doses of alpha-lipoic acid may promote oxidation, alter liver enzymes, and place strain on liver and breast tissue (38, To date, very few studies have looked at the safety of alpha-lipoic acid in children and pregnant women

M., Mullally, J

Two additional SNPs in the same gene, rs3740066 GG and rs12826 GG, have been associated with an increased risk to develop neuropathy following vincristine treatment, presumably due to increased accumulation of vincristine in neuronal cell bodies leading to increased neurotoxicity (Lopez-Lopez et al., 2016)