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Sandstrom et al., 2017), solitary nucleus, and catecholaminergic neurons in the pituitary-adrenal system (Edmonds and Edwards, 1996), all of which subsequently decrease the dopamine concentration in the brain (Barbeau et al., Studies have indicated that PQ dopaminergic neurotoxicity is associated with increased cellular oxidative stress and neuroinflammation, which induces -synuclein aggregation and impairs neurons (Manning-Bog et al., 2002

Amantadine (Symmetrel) can be taken in multiple daily doses, or in an extended-release formulation (Gocovri) that maintains a high level of amantadine in the body throughout the day and has shown good results in reducing dyskinesia