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doi:10.1016/j.freeradbiomed.2014.12.004

The authors emphasized that these pharmacokinetic limitations result in low plasma and tissue concentrations of curcumin, necessitating formulation strategies such as adjuvants, nanoparticles, liposomes, or phospholipid complexes to improve its bioavailability and therapeutic efficacy across various disease models

In clinical gastroenterology, "leaky gut" is not a primary medical diagnosis like Crohn's disease or celiac disease.Increased intestinal permeability is a secondary consequence of underlying inflammation, dietary triggers, or microbiome dysbiosis

Mulica, P., Grunewald, A