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Ulcerative colitis in smokers, non-smokers and ex-smokers

Viruses 14:650 Xu C, Rafique A, Potocky T, Paccaly A, Nolain P, Lu Q, Iglesias-Rodriguez M, St John G, Nivens MC, Kanamaluru V (2021) Differential binding of Sarilumab and Tocilizumab to IL-6R and effects of receptor occupancy on clinical parameters

Thus, disorders of hereditary iron overload can cause iron deposition in tissues that might result in hypogonadism and impaired spermatogenesis, whereas severe iron deficiency can propagate anaemias that decrease gonadotropin release and sperm counts

These symptoms are generally not specific, but when they occur together, they can become noticeable